A Disease of Wealth in Squirrels

Most people look at my research and see self-experimentation. I see a new way to understand diseases of wealth (often called diseases of civilization). We get sick because we live differently than our long-ago ancestors. Self-experimentation is powerful enough to sort through the thousands of differences between modern life and long-ago life to find those that matter.

In an experiment about the value of circadian rhythms to chipmunks, Patricia DeCoursey, a professor of biology at the University of South Carolina, found that their value was revealed by stress created by wealth:

In one experiment she discovered that chipmunks without an internal circadian clock appear quite normal at first. They can survive in optimal conditions; during the first year after their internal clocks were disabled, “predation by weasels was minimal,” she says. But then the chipmunk population increased strikingly due to two successive years of abundant acorn crops in the forest. The weasel population also increased, following the growth of the chipmunk population. Under these more crowded conditions, the restless nighttime movements of the arrhythmic chipmunks in their burrows clued the weasels in to their locations, and predation increased dramatically. The weasels killed all but four of the 100 chipmunks in this population.

Breakthrough in Treating MS

When Paulo Zamboni’s wife came down with MS (multiple sclerosis), he was in an unusual position: He was a professor of medicine. Not only did he have technical expertise, he was going to care far more than than most MS researchers about finding a cure. (Likewise, when I suffered from early awakening, I had both technical expertise and cared more about finding a solution than any sleep researcher.)

Using ultrasound to examine the vessels leading in and out of the brain, Dr. Zamboni made a startling find: In more than 90 per cent of people with multiple sclerosis, including his spouse, the veins draining blood from the brain were malformed or blocked. In people without MS, they were not. [emphasis added] . . . More striking still was that, when Dr. Zamboni performed a simple operation to unclog veins and get blood flowing normally again, many of the symptoms of MS disappeared. . . . His wife, who had the surgery three years ago, has not had an attack since. . .
The initial studies done in Italy were small but the outcomes were dramatic. In a group of 65 patients with relapsing-remitting MS (the most common form) who underwent surgery, the number of active lesions in the brain fell sharply, to 12 per cent from 50 per cent; in the two years after surgery, 73 per cent of patients had no symptoms.

Clearly Dr. Zamboni has discovered something very important. Perhaps no true health breakthrough would be complete without appalling responses from powerful people within the biomedical establishment. The American MS society issued a comment on these findings that the rest of us can marvel at. According to them, people with MS should not get tested for malformed or blocked veins!

Q: I have MS. Should I be tested for signs of CCSVI?
A: No, unless you are involved in a research study exploring this phenomenon, since at this time there is no proven therapy to resolve any abnormalities that might be observed, and it is still not clear whether relieving venous obstructions would be beneficial.

Persons with MS cannot be trusted with the dangerous knowledge of whether or not their veins are malformed or blocked! The Chairman of the Board of the National MS society is Thomas R. Kuhn. The President is Joyce M. Nelson. I would love to know how they justify this position. I wrote to the National MS society asking how Kuhn justifies this. The Canadian MS society is far less negative, perhaps due to public pressure.

Over at This Is MS, the National MS position is derided. Someone has made the shrewd observation that if there is something to Zamboni’s idea, persons with MS should get a red head after exercise more often than persons without MS and is collecting data to see if this is true. There seems to be something to it.

Not only is this a wonderful discovery but it is wonderful how the National MS Society can simply be ignored. There are now much better sources of information.

Thanks to Anne Weiss, Charles Richardson, and James Andwartha.

Splenda Reduces Gut Bacteria in Rats

This 2008 study done at Duke University found that small amounts of Splenda — similar to what a person might consume — reduced “beneficial bacteria” in the guts of rats. The effect was very large (reduction by about 50% in 12 weeks) and occurred even at the lowest dose, which was lower than what the FDA allows. Most ominous of all, the effect had not levelled off after 12 weeks. The number of bacteria was still going down.

Within a day two different people told me (in the comments to this blog) about this study, which was published a year ago. A press release about the study. The research was funded by the Sugar Association. Someone recently told me that the only way doctors learn about bad side effects of this or that drug is when drug reps selling competing drugs tell them. While reading about this I came across this chilling comment:

Excitotoxins are implicated in Parkinson’s as well… makes you wonder about Michael J. Fox – his time as Diet Pepsi’s spokesperson and his admitted addiction to the stuff for decades. I remember seeing an interview with him. His head was shaking from the Parkinson’s and his Diet Pepsi was right next to him.

One of the authors of the Duke study is a professor of psychiatry, Susan Schiffman. An earlier study of hers had pro-Splenda results.

More The makers of Splenda issued a press release that could not be less convincing. The study, it says, has “major deficiencies” that include “a lack of appropriate control groups necessary for understanding results.” No statement of what those control groups are. The press release also claims that because the investigators did not measure food and water intake, the results are meaningless! The idiotic press release is made even more curious by the statement quoted in the comments below, that “Drs. Abou-Donia and Schiffman admitted that some of the results recorded in their report submitted to the court were not actually observed or were based on experiments that had not been conducted.” But these, too, are not described. Which means to me that the details are not on Splenda’s side, or they would have been presented. It sounds like really bad news for Splenda.

Acid Reflux is Immune Problem, Says Rat Study

A study using a rat model of acid reflux found that the problem is inflammation caused by the immune system, not stomach acid damaging tissue, as had previously been thought.

[The] study in rats showed that gastroesophageal reflux causes tissue in the esophagus to release immune chemicals called cytokines, which attract inflammatory cells. These cause the heartburn and chest pain that make GERD [gastroesophageal reflux disease] so distressing.

“Currently, we treat GERD by giving medications to prevent the stomach from making acid,” said Dr. Rhonda Souza, who led the study published in the November issue of Gastroenterology.

“But if GERD is really an immune-mediated injury, maybe we should create medications that would prevent these cytokines from attracting inflammatory cells to the esophagus and starting the injury in the first place.

Months ago I posted about a friend of mine whose acid reflux was cured by drinking kombucha. The implication of that case and the rat study is that acid reflux is caused by an over-active immune system. Perhaps stomach acid often gets into the esophagus. Only if your immune system is under-stimulated does this cause trouble.

Acid reflux is very common. According to the article, 20% of Americans “have it regularly”. All this supports my view that we need plenty of bacteria in our diet to be healthy, that few Americans get enough bacteria in their diet, and that the deficiency causes all sorts of digestive and immune problems.

Interview with Tyler Cowen

Tyler Cowen’s new book Create Your Own Economy: The Path to Prosperity in a Disordered World has a lot to say about two topics in which I am especially interested: autism and human diversity. What can the rest of us learn from people with autism? What does the wide range of outcomes among autistic adults tell us about our world? I interviewed Tyler by email about his book.

ROBERTS If I remember correctly, you think a book should be new, true, and something else. What’s the something else?

COWEN The “something else” should cover at least two qualities.

First, if everyone read the book and was persuaded by it, would anything change for the better? An author should aim to write a book which matters.

Second, the book should reflect something the author really cares about. If the author doesn’t care, why should the reader?

ROBERTS What was the tipping point for this book — the event that made you say: I’m going to write a book about THIS?

COWEN To me it’s very important what an author is thinking about in his or her spare time, if the phrase “spare time” even applies to my life, which has an extreme blending of work and leisure time. Ideally that is what an author should be writing about. At some point you realize: “Hey, I am constantly thinking about xxxxx in my spare time!” And then you want to write it up.

I also hit up the idea of this book through pondering the lives of some particular individuals I know — and how much they *live* the thesis of my book — although I am not sure they would wish to be identified publicly.

ROBERTS Have you been to Autreat, the annual conference of Autism Network International, that you mention? If so, did it affect your thinking?

COWEN I haven’t been to Autreat, which for me is located somewhat inconveniently away from major cities (that is on purpose, I believe). I’m also not clear on exactly who is welcome, who needs an invitation, etc. Most conferences have a very high variance in quality across presentations and mostly one goes to meet one or two key people; often you don’t know in advance who they will be. I suspect the same logic applies to Autreat as well.

ROBERTS Do you think there are jobs that persons with autism do better than persons without autism?

COWEN Autistics often exhibit superior skills in attention to detail, pattern recognition, what I call “mental ordering,” and they have areas of strong preferred interests, in which they are very often superb self-educators. So yes, that will make many autistics very good at some jobs but also poorly suited for others. But I don’t want to generalize and say “autistics are better at job X,” that would be misleading. Across autistics there is a wide variety of cognitive skills and also problems. Engineering and computer science are the stereotypical areas where you expect to find higher than average rates of autism. While I suspect this is true in terms of the average, it can be misleading to focus on the stereotype precisely because of the high variance of skills and outcomes among autistics. One of the central issues in understanding autism is grasping the connection between the underlying unity of the phenomenon and the extreme variability of the results. In the short run, positive stereotypes can perform a useful educating function. But the more we present stereotypes, the more we are getting people away from coming to terms with that more fundamental issue, namely an understanding of the variance.

ROBERTS There is a basic biological phenomenon in which animals and plants under stress become more variable. Some say variability in the genotype has been released into the phenotype. Do you think the variance seen in autism has been “released” in some way?

COWEN I am not sure I understand the question…for one thing I am not sure what is the postulated increase in genetic stress…

ROBERTS Yes, it’s a confusing question. Let’s try this: What do you think the high variance of outcome seen in autism is telling us?

COWEN I’ll try to make that more concrete. One view of autism is that autistics have greater access to lower-level perception and such that access is essential for understanding autism. On one hand it gives autistics some special abilities, such as pattern recognition, certain kinds of information processing, and noticing small changes with great skill. (In some cases this also leads to savant-like abilities.) This also may be connected to some of the problems which autistics experience, such as hyper-sensitivities to some kinds of public environments.

It could be that non-autistics have a faculty, or faculties, which “cut off” or automatically organize a lot of this lower level perception. The implication would be that for autistics this faculty is somehow weaker, missing, or “broken.” The underlying unity in autism would be that this faculty is somehow different, relative to non-autistics. The resulting variance is that the difference in this faculty gives rise to abilities and disabilities which very much differ across autistics.

That’s one attempt to come to terms with both the unity of autism and the variance within it. It’s a tough question and we don’t know the right answer yet, in my view. What I outlined is just one hypothesis.

ROBERTS A clear parallel in the increased variance of autistic persons is the increased variance of left-handers. Left-handers have brain organizations that vary much more than the brain organization of right-handers. Right-handers are all one way; left-handers are all over the place. Do you see any similarities between left-handers and persons with autism?

COWEN I recall some claims that autistics are more likely to be left-handed but I’ve never looked into their veracity. There are so many false claims about autism that one must be very careful.

ADHD is another example of something which produces high variance outcomes. I don’t think it is correct to call it a disorder *per se*.

We’re just starting to wrap our heads around the “high variance” idea. Most people have the natural instinct to attach gross labels of good or bad even when a subtler approach is called for.

ROBERTS The term left-hander is confusing because left-handers aren’t the opposite of right-handers. The dichotomy is okay but the two sides are better labeled right-handers and non-right-handers. In other words, one group (right-handers) has something (a certain brain organization); the other group doesn’t have that brain organization. Then the vast difference in variance makes sense. How accurate would it be to say that non-autistics have something than autistics don’t have? (I’m left-handed, by the way.)

COWEN I would say we still don’t have a fully coherent definition of autism. And “have” is a tricky word. I think of autistic brains as different, rather than “normal” brains with “missing parts.” Some researchers postulate differences in the kind of connections autistic brains make. In thirty years I expect we will know much, much more than we do right now.

ROBERTS I hope this isn’t too self-indulgent: What do you make of the correlation between autism and digestive problems?

COWEN I don’t think there are convincing theories about either digestive problems causing autism or autism causing digestive problems. There is *maybe* a correlation through a common genetic cause, but even if that is true it is not very useful as a means of understanding autism. This is another area where there are many strong opinions, often stronger than are justified by the facts.

ROBERTS Another “assorted” question: I loved the study you mentioned where people with perfect pitch were more likely to be eccentric than those without perfect pitch. That’s quite a result. How did you learn about it?

COWEN There is a somewhat scattered literature on music, cognition, and society. It still awaits synthesis, it seems. Someone could write a very good popular book on the topic. (Maybe Gabriel Rossman is the guy to do it.) The more I browsed that literature, the more interesting results I found.

ROBERTS I don’t think I’ve done justice to your extremely original book but here is a last question. You talk about Thomas Schelling’s use of stories. Presumably in contrast to other econ professors. I think of story-telling being something that once upon a time everyone did — it was the usual way to teach. Why do you think Schelling told stories much more than those around him?

COWEN Thanks for the kind words. Schelling has a unique mind, as anyone who has known him will attest. I don’t know any other economist or social scientist who thinks like he does, but we’ve yet to figure out what exactly his unique element consists of. I would say that Schelling views story-telling as a path to social science wisdom. They’re not even anecdotes, they’re stories. Maybe that doesn’t sound convincing to an outsider, but it got him a Nobel Prize.

I am very interested in the topic of “styles of thought in economics.”

Depression and Insomnia Linked at CureTogether

Fourteen years ago I woke up one morning and felt really really good: cheerful, eager, and yet somehow serene. I was stunned: There was no obvious cause. I hadn’t slept particularly well. Nothing wonderful had happened the day before. But there was one thing . . . the previous day I’d watched a tape of Jay Leno right after waking up. I’d thought it might improve my sleep. Now — a day later — my mood was better. Could there be a connection? Two very rare events: A (TV early in the morning) and B (very good mood upon awakening). Did A cause B? Such causality would be far different than anything we’re familiar with. Yet it made some sense: From teaching introductory psychology, I knew that depression and insomnia are related. If you have one you are more likely to have the other. I had done something to improve my sleep; had it improved my mood? The already-known depression-insomnia linkage made the new idea, the cause-effect relation, far more plausible. Subsequent experiments led me to a whole new theory of mood and depression.

CureTogether has found another example of the familiar depression-insomnia correlation. Persons with depression are twice as likely to have insomnia as persons without depression. CureTogether gathered this data much more cheaply than previous studies. Unlike previous researchers, they were under no pressure to publish. (Professional researchers must publish regularly to keep their grants and their job.) Unlike previous researchers, they were under no pressure to follow a party line.

On the face of it depression makes you less active. Yet insomnia is a case of being too active. So the depression-insomnia link is far from obvious. Lots of other facts connect depression and circadian rhythms; they all suggest that the intellectual basis of anti-depressants, all that stuff about serotonin and neuro-transmitters and re-uptake, is wrong. If depression is due to messed-up circadian rhythms, taking a drug at random times of day is unlikely to fix the underlying problem.

BoingBoing on Natto

This post by Lisa Katayama told me a few things I didn’t know — especially that there is “good soy” and “bad soy”. Good soy is mainly fermented (soy sauce, miso, and natto). The book she mentions (The Jungle Effect by Daphne Miller), which I didn’t know about, sounds interesting.

Katayama’s series about food has the global title “Taste Test” so I was disappointed she didn’t compare different brands. I have done natto taste tests. The big difference between brands is the sauce packets! This is not how taste tests are supposed to turn out. Natto has a mild flavor that doesn’t matter if you add sauces. The texture is very similar across brands.

Thanks to Bryan Casteneda.

Best TV Season Ever

Here are my favorites (better to worse):

  1. Mad Men.
  2. Glee.
  3. Lie to Me.
  4. The Good Wife.
  5. Survivor.
  6. Amazing Race.
  7. Ugly Betty.

Most seasons I might like three shows as much or more than I like Ugly Betty this season. In most seasons Amazing Race would be in the top three. And 60 Minutes, Frontline, 30 Rock, and Modern Family are watchable. Lie to Me and The Good Wife have both managed to make a case-of-the-week show seem fresh, new, and complex.

Obesity and Your Commute

In the 1950s — before the invention of BMI (Body Mass Index) — Jean Mayer and others did a study of obesity at a factory in India. They divided workers by how much exertion their job required. Almost everyone, even desk clerks, was thin, with the exception of the most sedentary. It appeared that walking one hour per day (to and from work) was enough to get almost all the weight loss possible with exercise. Doing more had greatly diminished returns. A study with rats suggested the same thing. Bottom line: If you’re sedentary, you can easily lose weight via exercise, which can be as simple as walking to work. If not, it’s hard.

This month GOOD has a kind of update of that ancient study — a scatterplot, each point a different country, that shows percentage of obesity and fraction of commutes that are active (bike or walk). It supports what Mayer and others found — that how you get to work makes a difference. If you fitted a line to the data it would have a negative slope (more obesity, less active commutes). America has the most obesity and relatively few active commutes; Switzerland has the most active commutes and relatively little obesity. The graph also suggests that other factors matter a lot. Although Australia has less active commutes than America, it also has less obesity.