Apparently Pfizer Pharmaceuticals, the biggest drug company in the world, needs all the bad publicity it can get. One of the last things Jane Jacobs wrote was a friend-of-the-court letter in the Supreme Court case Kelo v. New London where eminent domain was used to take property from private landowners and give it to a private corporation (Pfizer). It was just as outrageous as that sounds. And Pfizer got away with it. Now Pfizer is abandoning the site. Leaving a large empty lot where houses used to be. The CEO of Pfizer is Jeff Kindler.
Month: November 2009
Chatting With a Gmail Hacker
Someone broke into my gmail account. (I have regained control.) The hacker sent an email to about twenty people asking for money. To be sent to London. Here is a gchat conversation that ensued (me = the hacker, Richard = one of my students):
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16 minutes |
Name – Seth Roberts
Location – 27 Leicester Square, London. England.
The Return of Charles “Disgraced” Nemeroff
So soon! Nemeroff, you may remember, took large sums of money from drug companies and failed to disclose them. What is that line about teaching an old dog new tricks? Here is what the New York Time s said:
The program, conducted online, had been led by Dr. Charles Nemeroff, an Emory University psychiatrist who last year was removed as department chairman and lost federal grant financing for failing to report income from 16 drug companies.
Dr. Carroll said that the program concealed unfavorable data and side effects of drugs made by AstraZeneca, which sponsored it, and played down alternatives to those drugs. In his complaint, Dr. Carroll wrote that the program “appears to make a mockery” of standards against bias.
In an e-mail message Tuesday night, Dr. Nemeroff defended the program. “The program was peer-reviewed and found to have fair balance,” he wrote.
Thanks to Michael Bowerman.
Pork Scrap
In a New Yorker podcast, Calvin Trillin says:
I live in Nova Scotia in the summer. And I hear a lot of talk about how Newfoundlanders eat mainly pork scrap.
Hey, that’s what I eat: pork scrap. (And fermented food.) Pork scrap (large pieces of pork belly, actually) is absurdly cheap: $1/pound or less.
Gatekeeper Syndrome
If the original Milgram obedience experiment weren’t scary enough, in the 1960s a researcher named Hofling did a variant in which nurses were ordered to give twice the maximum dose of a certain drug. The drug was not on the hospital’s approved list, the order was given by phone, and the nurse didn’t know the doctor giving the order. Yet 21 out of 22 nurses obeyed. (They were stopped just before giving the drug.) Hofling concluded that of the several intelligences that might have been involved in the situation, one was absent.
I thought of this research when I learned about a remarkable case of anaesthesia dolorosa. Anaesthesia dolorosa is a condition where you lose sensation in part of your face and have great pain in that area. It’s rare; it’s usually caused by surgery. In 1999, Beth Taylor-Schott’s husband had an operation for trigeminal neuralgia that left him with this condition. In the ensuing years, all sorts of pain medications failed to solve the problem. Then he had another operation:
In January of 2008, David underwent a gamma knife procedure to ablate the sphenopalentine nerve bundle. Before the procedure, we were told that 16 other patients had had the procedure, and that all of them had experienced either complete recovery without drugs or an 80% reduction in pain. So we were optimistic going in. It was only after they had done the surgery that the doctors admitted that they had never done it on someone with AD before and that all those other patients had had atypical facial pain. The surgery had no effect as far as we could tell.
Shades of my surgeon claiming the existence of studies that didn’t exist. But that’s not the point. The point is this: After reading Atul Gawande’s article about mirror therapy for phantom limb pain, she and her husband tried it. “Within 2-3 days, his pain was down to zero.” It stayed there so long as they continued the mirror therapy. Soon after this they were able to eliminate his pain medication.
I asked Taylor-Schott what the reaction of her husband’s doctor was. She replied:
David’s actual pain doctor wrote back a single word, if I remember correctly, which was “fantastic.”
Wow. An incurable debilitating pain condition quickly and completely eliminated without drugs or danger or significant cost and . . . a pain doctor isn’t interested. Let’s call it gatekeeper syndrome: lack of interest in anything, no matter how important to your work, that doesn’t involve you being a gatekeeper.
I said that showed remarkably little curiosity. Taylor-Schott said that was typical. I agree. After I lost 30 pounds on the Shangri-La Diet, my doctor expressed no curiosity how I had done so. A friend of mine showed his doctor some data he had collected highly relevant to how to treat his condition; his doctor wasn’t interested.
Curiosity is part of intelligence. Not measured on IQ tests — a serious problem with those tests. To lack curiosity is to be just as brain-dead, in a different part of the brain, as those too-obedient nurses. Taylor-Schott speculated that curiosity was beaten out of doctors in medical school. Or perhaps much earlier. Curiosity doesn’t help you get good grades in college.
In my experience, college professors have their own problems along these lines. UC Berkeley has a fantastic selection of talks, year after year. I almost never saw a professor at a talk in a department different from his own — no psychology professor (other than me) would attend a talk in nutrition, for example. At statistics talks, I almost never saw a professor from another department. Curiosity had been beaten out of them too, perhaps. Professors who lack curiosity produce students who lack curiosity . . . it makes sense. It sort of explains why Berkeley professors had/have a such a narrow view of intelligence; to them being smart means being good at what college professors do. It also explains why the lack of measurement of curiosity on IQ tests is so rarely pointed out.
And it explains why Taylor-Schott and her husband learned about mirror therapy from a magazine article rather than from one of the many pain doctors they consulted.
A Chinese Joke
In a Shanghai apartment, the phone rings. A friend of the occupant answers the phone. “It’s someone from a rural area,” he shouts to the occupant. (Shanghai and other dialects are quite different.) “I’m from Beijing,” says the person on the line. “It’s someone from Rural Beijing,” the friend shouts.
This joke is told by people who are from neither Shanghai nor Beijing.
Leonard Mlodinow on Wine Experts
In France, a decade ago a wine researcher named Fréderic Brochet served 57 French wine experts two identical midrange Bordeaux wines, one in an expensive Grand Cru bottle, the other accommodated in the bottle of a cheap table wine. The gurus showed a significant preference for the Grand Cru bottle, employing adjectives like “excellent” more often for the Grand Cru, and “unbalanced,” and “flat” more often for the table wine.
Whether a wine wins a medal in a competition appears to be pure chance:
Mr. Hodgson restricted his attention to wines entering a certain number of competitions, say five. Then he made a bar graph of the number of wines winning 0, 1, 2, etc. gold medals in those competitions. The graph was nearly identical to the one you’d get if you simply made five flips of a coin weighted to land on heads with a probability of 9%. The distribution of medals, he wrote, “mirrors what might be expected should a gold medal be awarded by chance alone.”
Thanks to Dave Lull.
Dance Dance Revolution
Just as addictive as everyone said. It reminds me of racquetball, which I could play for hours. But racquetball required going to the gym, getting dressed, finding someone to play with, waiting for an empty court, coming home. It might be possible to use my DDR scores as a measure of something.
More Black-and-White Thinking
Here’s part of a speech that Geert Wilders, the Dutch politician, gave in New York in February:
There might be moderate Muslims, but there is no moderate Islam. Islam will never change, because it is built on two rocks that are forever, two fundamental beliefs that will never change, and will never alter. First, there is the Quran, Allah’s personal word, uncreated, forever, with orders that need to be fulfilled regardless of place or time. And second, there is al-insal al-kamil, the perfect man, Muhammad the role model, whose deeds are to be imitated by all Muslims. And since Muhammad was a warlord and a conqueror we know what to expect. Islam means submission, so there cannot be any mistake about its goal. That’s a given. It’s fact.
Whereas here’s what a friend of mine living in Amsterdam sees:
Disenfranchised immigrants who were summoned here to do low skilled jobs, aspire to integrate into Dutch society, but are often systematically excluded by Dutch people. Â A lot of them don’t have much formal education. That doesn’t help.Even 2nd and 3rd generation Moroccan immigrants, many of whom are nice people and speak perfect Dutch, get treated like underclass by native Dutch people. Â It angers and depresses the parents, who feel shut out, and their kids suffer also.I find it terribly sad to think that the kids I fix bikes with have such a disadvantage due to their origin. Many of them are quite smart. It strikes me as such a waste of human potential.
There are some nice Dutch people who get along fine with the immigrants, but not very many.
They’re describing the same thing!
The Parable of the Wii
For exercise (Dance Dance Revolution) and self-tracking, I decided to buy a Wii. My first attempt, I was scammed. It arrived in August. With difficulty, I took it and accessories unopened to China. That was hard. It was even harder — for no obvious reason — to install it in China. The box sat unopened next to my TV, easily visible, for two months.
Finally I opened the box, took out the parts, put them together, added batteries, plugged it into the TV in my apartment. And nothing happened! Was my TV at fault? Or the Wii? Wii’s aren’t sold in China. I imagined bringing it back to America to get the problem fixed. After a few days, I tested my TV using video output from a neighbor’s Apple computer. My TV worked. After the test, my Wii also worked. When I replaced the Apple input with the Wii input I saw the Wii input for the first time. I don’t understand it, but that’s what happened.
In my experience, this is how science works. It is much harder than expected, then it pays off in ways that defy understanding. The concept of self-experimentation is simple: I will measure X (sleep, productivity) about myself. I will test different ways to improve X, learn what works, and thereby improve X. The reality is different. For years I measured my sleep and tried to improve it. It was hard to deal with the data. Even worse, every idea I had was wrong. That seemed like a huge obstacle — like my Wii needing repair. But I kept plugging away, because it was better than doing nothing, and . . . got somewhere. Out of nowhere and nothing. Not only did I improve my sleep, I arrived at a broader idea about health that turned out to be very helpful (that our bodies are designed for Stone-Age conditions and self-experimentation can help determine those conditions, which aren’t obvious). Just as we overvalue big steps (e.g., well-funded prestigious research), we undervalue small ones (e.g., cheap research with no prestige).
Science is basically a bunch of little steps. Many little experiments that explore cause-effect space. If you find a new example of cause and effect, the payoff is unpredictably large. Scientists don’t like thinking of themselves as wandering ants. But that’s how they are most effective. This goes against human psychology because wandering (Nassim Taleb calls it “tinkering”) is low status and lonely. The payoff is too rare and too unclear. It isn’t supported by powerful institutions, such as research universities and medical schools. Imagine an ant who says “I know where food is!” This is a way to get many ants to follow him, to feel important, to have high status, to get support from his employer. That’s why he does it. But he doesn’t know. The effect on the rest of us, the potential beneficiaries of progress, is that instead of having a thousand ants wandering everywhere, we have a thousand ants following one ant who doesn’t know what he’s doing.