Why Are Colds and Flu More Common in Winter?

The effect is so large, so easy to notice, it is enshrined in the word cold. We get far more colds and flu in the winter (“flu season”) than in the summer. In this excellent interview, epidemiologist Thomas Jefferson asks:

Why, for example, do we not get influenza in the summertime?

All of the possible explanations listed in this Wikipedia article assume that it is cold weather that makes flu more common in winter. However, an impressive 1981 study found that flu peaked during the light minimum, not the temperature minimum, contradicting all of these explanations.

My proposed explanation is that flu is less common in the summer because people sleep better during the summer. They sleep better in the summer because they get more morning light. More morning light causes your circadian system to have a greater amplitude, which means you sleep more deeply. Better sleep –> better immune function. When I started to sleep much better, I stopped getting noticeable colds and flu.

When I wrote my paper it was essentially impossible to test my idea. You need to measure a lot of sleep — and sleep scientists, intent on making it hard to do what they do, have made this nearly impossible. Perhaps it will soon be easier. To begin with, to test my idea you’d need to improve sleep somehow. To get more light exposure during winter is easy enough with a light box but measuring quality of sleep is much harder. Maybe FitBit (which will start shipping in a few months) will make this possible. I tried using SleepTracker to measure my sleep but after a few months I gave up. There were four big problems: 1. The interface didn’t work very well. It was often hard to get the data from the device into my computer. 2. The whole thing wasn’t designed to measure sleep, it was designed to wake you at a better time than you would wake up without it. 3. The way it measured sleep was a secret. 4. The output — the measure of sleep — was binary. All you were told was whether movement was above or below some threshold. And I had no idea how that threshold was determined.

Assorted Links

Thanks to Carl Willat, Peter McDonnell, Stephen Marsh, and someone else whose name I cannot find.

How to Base Medicine on Evidence

The thing to notice about what the New York Times calls “ the evidence-based medicine practiced at Intermountain hospital” is how different it is than the movement called evidence-based medicine. The Intermountain stuff, above all, is not black-and-white thinking. It is a good example of what the opposite looks like. The rules aren’t simple, they are complex, and not fixed. It is what engineers in other areas have been doing since Deming.

So many scientists — not to mention everyone else — are completely paralyzed, rendered completely useless, by their black-and-white thinking. It feels good to them — they love the certainty of it, and the power it gives them to look down on others — and they never quite realize what it has done to them. The notion of using evidence to improve health care made perfect sense — until black-and-white thinkers got a hold of it.

Any class in scientific method should be at least half about avoiding black-and-white thinking. They never are.

Saturated-Fat Epidemiology

Here, at Free the Animal, are three scatterplots that show better health (less heart disease, less stroke) correlated with more saturated fat (= animal fat) in the diet. Each point is a different European country (Albania, Bulgaria, etc.). Small and large countries show the same relationship.

The obvious confounding is with wealth — rich people eat more meat than poor people. Were this data submitted for publication, I imagine someone would say how dare you fail account for that! and reject the paper. That would be a mistake. Because it is hard to look at this data and continue to think that saturated fat is the evil it is made out to be. And of course whatever the weaknesses of my sleep/fat experiment (which showed animal fat improved my sleep), confounding with wealth was not one of them.

Jiaweishop.com Scam

If you look on this blog you will find several other website names that this site has used to scam people, such as myshopinsun.com. You will pay via PayPal, complain to PayPal, PayPal will “investigate”, decide you were right — and not give you your money back. That PayPal keeps helping whoever is behind this is curious and infuriating to anyone scammed.

Nassim Taleb on Incompetent Experts

Via Proinvests.com, Nassim Taleb said this:

I was in Korea last week with a collection of suit-wearing hotshots. On a panel sat Takatoshi Kato, IMF Deputy Managing Director. Before the discussion he gave us a powerpoint lecture showing the IMF projections for 2010, 2011, …, 2014. I could not control myself and got into a state of rage. I told the audience that the next time someone from the IMF shows you projections for some dates in the future, to show us what they PROJECTED for 2008 and 2009 in 2004, 2005, …, and 2007. They would then verify that Mr. Takatoshi and his colleagues provide a prime illustration to the “expert problem”: they serve as experts while offering the scientific reliability of astrologers. Anyone relying on them is a turkey.

This allowed me to show the urgency of my idea of robustness. We cannot get rid of charlatans. My point is that we need to build a society robust to charlatanism and expert-error [emphasis added], one in which Mr. Takatoshi and his staff can be as incompetent as they want without endangering the general public. We need less reliance on these people and the Obama administration has been making us more dependent on the “expert problem.”

I completely agree. This highlights two hidden strengths of self-experimentation.

First, the more you can rely on data about yourself, the less you need to rely on data from other people, which until recently — internet forums, CureTogether.org, PatientsLikeMe.com — almost always came to you through experts (usually doctors), who filtered it to suit their purposes. When I was a grad student, I had acne. My dermatologist prescribed tetracycline, a powerful and dangerous antibiotic. Studying myself, I quickly figured out tetracycline didn’t work. My dermatologist had failed to figure that out — that it didn’t work in at least some cases. In his practice, he must have encountered examples of this, but he ignored them. It served his purposes to think it worked. That’s one sort of filtering: Ignoring inconvenient data. Self-experimentation made me less reliant on my dermatologist.

Second, self-experimentation allows researchers such as myself to do innovative research in some area without getting permission from experts in that area. Self-experimentation is very cheap; no grant is required. A self-experimenter can be as heretical as he cares to be. My research on weight control has been breezily dismissed by nutrition professors, for example. Obviously they wouldn’t fund it. The Animal Care and Use Committee at UC Berkeley turned down my application to do rat research about it — my ideas couldn’t possibly be true, they said. My research on mood isn’t just utterly different than what clinical psychologists and psychiatrists say to each other in meetings and papers; it also, at first glance, sounds absurd. Self-experimentation allowed me to do it. That’s another sort of filtering: control of what research gets done.

I don’t think conventional research in nutrition, clinical psychology, or psychiatry is worthless — far from it. I think it is very valuable. (For one thing, it helped me see that my self-experimental conclusions, as unorthodox as they were, had plenty of empirical support.) What is hard for outsiders to grasp is how what they see — what they read in magazines and newspapers and even books — is heavily filtered to conform to a party line. Plenty of research supports the Shangri-La Diet, for example (such as research about the set point theory of weight control), but you are unlikely to read about it in, say, The New Yorker because it doesn’t fit conventional ideas. Plenty of conventional research supports my ideas about mood, but you are unlikely to read about that research because it doesn’t support the party line of “dopamine imbalance” causing depression or whatever. This is what Leonard Syme taught his public-health students — that the party line was a lot more questionable than an outsider would ever guess. They hadn’t heard that before. (And it was unpleasant: Uncertainty is unpleasant.) This is a third sort of filtering: What data reaches outsiders.

I never had a teacher like Leonard Syme — I’ve never even heard of someone else doing what he did — but self-experimentation taught me the same thing. I came to see the fragility of mainstream claims about all sorts of things related to health. As Taleb says, we are used to thinking the charlatans are on the fringes. But they’re not — there’s plenty of them at the centers of power.

Thanks to Dave Lull. Frontline’s recent show “The Warning” makes the same point as Taleb, that there is great incompetence at the highest levels of power.

Sickness After Starting to Eat Yogurt

A friend writes:

As of today I’m getting over my fourth cold since I began eating lots of yogurt (maybe 1-2 cups a day, homemade), which was roughly in March of this year. So that would be a rate of about a cold every two months. On the one hand that sounds pretty terrible. On the other hand, a couple of things to think about:

1. I used to always get colds and other sicknesses as well. They just seem to be attracted to me. By my intuition, the current rate doesn’t seem particularly unusual, although I never kept track before. If anyone had a cold anywhere around me, invariably I got it. It’s been that way as long as I can remember, especially when I was traveling, as I have been during these last few months.

2. Each of the colds I have had in this last eight month period has been remarkably short. Really remarkable, so I will remark, by way of example, that this cold came out of the blue yesterday evening with a fit of sneezing. I hadn’t felt bad at all earlier in the day although in retrospect it’s possible I was a bit worn down (or maybe not: I took a half-hour swim in the late afternoon and felt pretty good). So I sneezed my way through an evening, nose dripping like a faucet. Before going to sleep I took some sort of medicine for cold symptoms (maybe something made by Bufferin maybe? Night/day something…), and in the morning I took the same thing (day version). During that whole time I was still pretty symptomatic: sneezing, nose dripping etc., but I guess the medicine might have been somewhat useful. Now here it is 2:30 in the afternoon and all of a sudden I realize my nose is dry and I haven’t sneezed for hours. I reckon this is about the end of the cold: less than 24 hours. The other three were like that as well: very quick onset, then disappearing almost before I could have time to realize I had a cold. For me this is particularly noteworthy because in years past I always seemed to get the worst of the colds, going on for days and often progressing into a hacking cough that would linger for weeks.

I suspect if my friend improved his sleep he would get see further improvement of these measures of illness. In this study, the frequency of sickness episodes went down for workers given a probiotic but their duration, when they happened, didn’t change — perhaps because it was nice to be away from work.

After I copy-and-pasted that, I got sick. It wasn’t sickness as most people know it. After an afternoon walk (1 hour) I felt tired; that was the first sign. After dinner, I felt really tired. That was an unmistakable sign. I went to bed early, slept about 8 hours (1-2 hours more than usual) and woke up rested. But an hour later I fell back asleep for 15 minutes. At that point I was sure something was wrong. I had a class that morning starting at 10 am. Should I cancel it? I got much more tired and, about two hours before class, was too tired to get out of bed to turn off the beeping yogurt maker. Okay, I’ll cancel class. I phoned the TA to cancel the class but he couldn’t — he had a bad cold. I phoned a student and she phoned the other students.

An hour later, however, I felt much better. By class time I felt well enough to go to class, although I walked rather than ride my bike. (The student did her best to uncancel the class.) In the afternoon I took a long nap (1.5 hours). The next day I was just barely more tired than usual. Today I feel completely well.

I was sick, yes, but without chills, runny nose, sneezing, sore throat — without any discomfort at all unless feeling tired counts as discomfort. And I felt distinctly more tired than usual for only about a day. I think this is what happens when your immune system works properly. You fight stuff off much faster than the five days or so many people take to get better. Before I figured out how to improve my sleep, I got the usual 4-6 colds per year. After I started to sleep much better, I never got sick in the usual runny-nose way so long as my sleep was good. The current episode is striking to me because I was more sick — that is, more tired — than usual. I do only two things to make my immune system work better: (a) improve my sleep in several ways (eat animal fat, get plenty of morning light, stand on one foot); and (b) eat plenty of fermented foods (mostly yogurt, but also miso, kimchi, natto, and kombucha).

UCLA: Livers For Sale

According to 60 Minutes,the UCLA Medical Center moved a notorious Japanese mobster to the head of the liver transplant line after he donated $1 million to the program. Thus imitating Mother Teresa, who became friends with the worst dictators in the world if they gave her enough money.

More UCLA receives a large amount of taxpayer money, both state and federal. None of those taxpayers appreciates losing a life-saving liver to a gangster who paid none of those taxes. It’s an extreme abuse of public trust.

Dietary Fat and the Brain

Over the last six months I’ve come to believe that animal fat improves my sleep. Because sleep is controlled by the brain, this suggests animal fat may also improve other measures of brain function, just as omega-3 turned out to improve brain function in a wide range of ways. I didn’t know about a recent experiment done with airplane pilots that supports that idea. This was the design:

A total of 45 pilots (mean age, 20.8 years; 87% male) from the [University of North Dakota] commercial-aviation program were enrolled in this 14-week repeated-measures crossover trial.

During the first week, participants were randomized to receive 1 of 4 diets (3 full meals and 2 snacks) for 4 days: a diet high in carbohydrates, a diet high in fat, a diet high in protein, or a control diet. After a 2-week “phase-out” period, all pilots then randomly received a different study diet. This process was repeated until all pilots had received all 4 diets.

I haven’t been able to find out much about the high-fat diet. Here are some of the results:

The response time on the Sternberg test of short-term memory was significantly faster for participants who ate the high-fat diet (< .05) than for those who ate the protein and control diets, especially at higher memory loads.

With sleep, however, the high-carb diet produced the best sleep.

Here is the abstract.

Thanks to Paul Sas.