Autism and Digestive Problems

A new study in Pediatrics has a brief but useful summary of the evidence linking autism and digestive problems. Here’s one study. Here’s a review, with this abstract:

Recent publications describing upper gastrointestinal abnormalities and ileocolitis have focused attention on gastrointestinal function and morphology in [autistic] children. High prevalence of histologic abnormalities in the esophagus, stomach, small intestine and colon, and dysfunction of liver conjugation capacity and intestinal permeability were reported. Three surveys conducted in the United States described high prevalence of gastrointestinal symptoms in children with autistic disorder.

There is also evidence that immune dysfunction is associated with autism.

I believe that few people in America eat enough bacteria — in practice, this means not enough fermented food — and that this causes digestive and immune problems. A vast number of people will say, “of course, good food is really important, bad food causes X, Y, and Z” — where X, Y, and Z can be practically anything. The difference between my views and theirs is the prescription: They inevitably think that people should eat more fresh unprocessed food. (Usually fruits and vegetables, for some curious reason.) Fermented food, of course, is not fresh and not unprocessed.

The Singapore Borders and the Power of Books

Around 1996, Borders opened a bookstore in Singapore. With about 50,000 books, it was much larger than any existing bookstore on the island. Freight cost about $1/book, a big improvement over the shipping costs if you bought a book online. Singapore, of course, is a very crowded place. Space was precious. You couldn’t own a lot of books because you didn’t have much space. One result was books were sold shrink-wrapped. The Borders books, however, were not shrink-wrapped. A great bookstore is like a great library — but only if the books aren’t shrink-wrapped. The first customers in the Singapore Borders would bring a book to the front desk and ask for the shrink-wrapped copy. But there was no shrink-wrapped copy.

Singapore newspapers started editorializing about how to behave in the new bookstore: Careful with the books. Handle them gently. They were trying to acclimate their readers to non-shrink-wrapped books. Why did editorial writers throw their weight behind a new business? Bruce Quinnell, the head of Borders at the time, thinks it is because they thought the new bookstore was such a wonderful thing. Thousands and thousands of books that had never before been on that island. Books are a commercial product but no other commercial product would inspire such a response.

The Singapore Borders was a huge success, at one point leading the entire chain in sales, and as far as I know is still thriving.

Uncharitable

Uncharitable: How Restraints on Nonprofits Undermine Their Potential by Dan Pallotta is more a howl than a book. I enjoyed opening it at random, reading a few pages, agreeing with the author that the current situation is idiotic, and then going back to whatever I was doing. It is too repetitive to read sequentially but read in bits it makes a lot of sense. His big point is that nonprofits are forced to operate under weird moralistic constraints that do no one any good — and I’m sure he’s right. The main benefit of those moralistic constraints — no one must profit from charity! for example — is that the moralizers feel good. The charities are badly damaged. And the charities are self-destructive, too. After Pallotta’s company ran highly successful 3-day Breast Cancer walks for several years, the Avon Products Foundation, which benefited from these walks, decided they could do better themselves. After a year (2002) in which Pallott’s company raised $140 million, Avon themselves ran a similar event for four years (2003-2006) during which they raised about $60 million/year.

Ode to Trader Joe’s: Update

A month ago, as I blogged, my friend Carl Willat posted on YouTube a video he’d made titled “ If I Made A Commercial For Trader Joe’s“. It has now received several hundred thousand views. I asked Carl for an update. He replied:

This video has received a better reaction than anything I’ve done in quite a long time. Â Of course part of this is just YouTube, where suddenly you can know what people think of your commercial, through the comments they leave and how many views you get. Â In the past commercials were just sent out into the ether and you never really heard any firsthand audience reaction. Â But some of my old commercials are on YouTube and none of them has this many hits. Â Even Christmas Kisses, which people really seem to like, has maybe 28,000 views in two years. And people aren’t posting it to their blogs or Facebook pages, as far as I know. Â So something is different about this one. Â To a large extent I’m trading on the goodwill people already have for Trader Joe’s. Â People just love that store. Â And the spot is subversive, which makes it more fun. Â But I think the main difference is the fact that it’s heartfelt, in that it reflects my actual feelings about Trader Joe’s, both positive and negative, and a lot of people can relate to those feelings. Â You can’t do that in a real ad because there’s an agency and a client that only want to say positive things about the product, and it has to be part of their overall strategy and so forth, which is fine, and I’ve certainly done my share of ads like that. But it’s hard to get genuine human feeling into traditional advertising, which is a shame, human feeling being the only thing people really care about.

The viewing history:

The spike happened after mention on Boing Boing.

I think Carl’s commercial is very important as a glimpse of the future. Long ago, only the powerful could speak to a mass audience — and they couldn’t tell the truth, for fear of losing their power. Then cheap books came along. Instantly a much larger group of people could speak to a mass audience — and, having little to lose, they could tell the truth. The truth, being rare, was an advantage. When science was young and many scientists were amateurs — Darwin, Mendel — they could tell the truth. As science became a job, a source of income and status that you could lose, scientists lost the ability to say what they really thought. For example, David Healy lost a job because he told the truth about anti-depressants. Self-experimentation is a way around this problem because, as I’ve said, no matter how crazy my conclusions I can keep doing it. I don’t need a grant so I don’t need to worry about offending grant givers.

Because TV commercials are a source of money and status (for ad agencies and marketing execs), they too have great difficulty being truthful. After watching Carl’s commercial I watched a Coke commercial that used the same music. The Coke commercial now struck me as horrible — flat and insincere. (Yet expensive.) Given the choice between an official statement — namely, the commercials you see on TV — and a personal one — a commercial like Carl’s — everyone will not only prefer to watch the personal statement but will also be more persuaded by it. Win-win. So it is in the self-interest of any company that makes a product that somebody loves to stop making the usual insincere stuff and start finding people who love their products and help them express it.

Where Does Umami Come From?

As previously blogged, the evolutionary reason we like umami taste may be so that we’ll eat more bacteria-laden food. This makes sense only if bacteria-laden food would have been the main source of umami. Nowadays, you can get umami from MSG. What about before MSG?

The Umami Information Center sent me a free booklet called Umami The World — a better title than Umami: An Introduction. Umami taste is mainly supplied by glutamic acid, a protein building block. My assumption was that glutamic acid is usually a protein breakdown product. Bacteria feed on protein, leaving a pile of bricks — glutamic acid among them. Was this correct? Or could you get umami taste without bacteria?

You can, but in most cases you don’t. In Japanese cooking, a potent source of umami is konbu, a type of seaweed. Perhaps because konbu produces so much umami and so little else that umami was discovered by a Japanese scientist. Umami flavorings are used in many other cuisines but the source is usually fermented food. In many Asian countries, umami comes from fermented fish sauce and fermented bean products (e.g., miso, soy sauce). In Chinese cooking, umami comes from a condiment called jiang, which is made from fermented grain, meat, or fish. In Western cuisines, cured pork is often used as a flavoring agent. “The curing process liberates more of the glutamic acid content of the meat.” Curing takes place at room temperature, which means bacteria grow. “Much of the food of ancient Rome was routinely seasoned with a sauce [that] was made from salted fish, fermented and strained. . . The polar Eskimo people traditionally fermented a small portion of their harvest of fish.” Tomatoes and shitake mushrooms are non-fermented sources of umami.

A telling comment in the book is that umami usually comes from sauces (e.g., fish sauce) or liquids (e.g., dashi, bouillion). Cooks use sauces and liquids to add what is missing. The presence of umami in so many sauces — as if sauces have been devised or selected to be high in umami — suggests that ordinary foods don’t have much umami. A table of glutamate concentration says that parmesan cheese has 1700 mg/100 g whereas several vegetables — tomatoes (246 mg/100 g), green pea (106), onion (51), spinach (48), potato (10) — and meats — beef (10), chicken (22), pork (9) — have much less.

The breakdown process I imagined is spelled out: “During the ripening of cheese, proteins are broken down progressively into smaller polypeptides and individual amino acids. Large increases in free amino acid content also occur during the curing of ham.” Surely the same will be true during room temperature aging of any protein source. Beef is routinely aged at room temperature for about a week to give it a “meaty” flavor (not from the umami book but from here).

Bees and Fermented Foods

I became interested in fermented foods less than two months ago but I’m sure I’ll be eating plenty of them for the rest of my life. The benefits have been very clear and — not that it matters — the intellectual case is strong. Being new to it, I have wondered how my ideas and habits might evolve.

I got a glimpse of a possible future from a comment on this blog by Heidi. She linked to a page about kombucha and probiotics and bee-keeping and later sent me a link to a discussion of using probiotics to keep bees healthy. A discussant named Tim Hall said this:

I once scratched open my index finger, and somehow caught an MRSA [Methicillin-resistant Staphylococcus aureus] infection so bad I was in the hospital for a week. This incident completely changed my perspective on chemical culture. Now not a day goes by that I don’t ingest some form of live cultured food…most of it I culture myself.

I make kefir on a daily basis. Kombucha I have not tried since I avoid caffeine. I also make my own sauerkraut, kimchi, koji, miso and koji pickles (and of course mead).

Hmm. I have never made kefir, but it’s not hard to make. I hadn’t even heard of koji, which is a kind of fermented rice.

Umami Burger

A new restaurant with the excellent name Umami Burger has just opened in Los Angeles. According to The Foodinista, the food is as good as the name:

An attractive space with an attractive clientele. The tightly edited menu consists of 10 burgers, and a few sides including fries and a market salad. But, we’re told at 12:45 pm on a Tuesday afternoon, they’ve run out of buns. . . . amazing homemade ketchup . . . The beef patties on all of the above, really flavorful and just plain GOOD. I don’t know how they can make such a great burger and charge so little. . . . I’m telling you, the burgers are great.

Review by Jonathan Gold.
Thanks to Tucker Max.