A Clinical Trial of Fish Oil

A big study of the effects of fish oil is taking place at Ohio State University. From its website:

The beneficial effects of fish oil (or eating fish more frequently) include reductions in triglycerides, blood pressure, and heart rate, as well as increases in HDL cholesterol, the “good” type of cholesterol. In addition, certain aspects of immune function also appear to show favorable responses to fish oil supplementation, and some studies suggest that fish oil helps to improve mood and decrease depression. This study is designed to examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects aspects of your immune response, and your mood; because some research suggests that people who eat more fish may do better during stressful times, the study will also examine how fish oil affects your immune response to stress, certain stress hormone responses, and your psychological response to stress.

I was especially curious how they are measuring brain function. Here’s how:

At Visit 1 and Visit 5 [16 weeks after Visit 1] only, you will be asked to perform various tasks for about 20 minutes; these will include making a short speech and computing arithmetic problems without pencil or paper in the presence of other research team members. You will be audiotaped while you complete these tasks. . . At Visit 1 and Visit 5 only, the researchers will administer short tests that measure aspects of memory and concentration to see if the fish oil supplements have positive effects on learning and memory. For example, you might be asked to memorize several words, and then you would be asked which of the words you remember several minutes later.

Each subject participates for 24 weeks. The study, which started in 2006, is supposed to end in 2010, with 138 subjects in two groups (69 per group).

Tyler Cowen’s experience with flaxseed oil implies that omega-3 supplementation can dramatically reduce inflammation within a few weeks. My research shows that omega-3 supplementation can improve brain function within a few hours. This study appears to be much larger than necessary.

The Academic Stockholm Syndrome

Today I went to a talk about terrorism. After the talk, I asked a question: What’s the evidence for the recommendations you made at the end? The speaker, a professor at Harvard, began her answer by apologizing: I can only tell you case-by-case anecdotes, she said. She repeated this apology a little later. Well, of course no one has done a controlled experiment (or any experiment) on how to deal with terrorism. Of course all we have is a story here, a story there. The speaker, whose talk was good, had heard the pervasive dismissiveness I criticize here so many times that not only did she expect it, she accepted it. The academic Stockholm Syndrome.

Fear-Mongering?

This post by Dr. Erika Schwartz, complaining about a breast cancer story in the NY Times, makes important points. When politicians — such as Joe McCarthy or Jean-Marie Le Pen — try to scare us, most of us appreciate the psychology involved: The more fearful we become, the more we will look to them to protect us, thus increasing their power. Our fear = their power. Schwartz is saying that respected doctors and journalists do the same thing. How prophetic was The Coming Plague (1994) by Laurie Garrett?

Schwartz’s post has too little detail to convince me that this particular story is guilty. Nor do I agree with her that statistics are “totally meaningless when applied to the individual.” Her contribution is to ask: how can we discuss these issues without fear-mongering?

A Bayesian Tries SLD

Bayesian data analysis, which Andrew Gelman has pioneered, is about taking one’s beliefs into account when doing data analysis. When I wrote The Shangri-La Diet, I was being a kind of Bayesian: I realized that the facts I had gathered so far did not establish the diet as any sort of panacea. Based on the facts in the book, it was hard to say how widely helpful the diet would turn out to be. I wrote the book anyway because the facts I had gathered so far were so surprising, so inconsistent with what almost everyone said about how to lose weight. From a Bayesian point of view — taking prior beliefs into account — they were impressive. If conventional views were right, no one should lose weight following SLD. But several people had. Some of them, such as Tim Beneke, had lost a lot of weight. To complain that there was no clinical trial, no certainty, was to miss the point that the book includes data that should have been impossible.

Whoever blogs at 4d2.org says something similar:

My first reaction to [SLD] was, of course, that it was one of the stupidest things I’d ever seen. Then I started reading the forums on the creator’s (Seth Roberts) site, and then I did some Googling. And would you believe that, in the absence of anything that I would call scientific evidence, this thing seems to work for most people that try it. . . . Five days ago I honestly believed the Shangri-La Diet to be hooey — interesting hooey, maybe, but still hooey. . . I decided I’d try it for myself and report on the results. I want to make it really clear that I approached this diet with a very healthy dose of skepticism. You should also understand that I’m a staunch advocate of the “eat right and exercise, stupid” philosophy of weight loss. I have never followed a prepackaged diet strategy. Having said all that: it works. I do not know why or how it works, but it works.

Why Are Medical Costs So High?

At Cato Unbound, David Cutler, a Harvard public policy professor whose research I used in The Shangri-La Diet, writes:

The most important reason why medical costs increase over time is because we develop new ways of treating patients and provide that care to ever more people.

At least in his essay, Cutler fails to consider an alternative explanation: Medical costs have increased a lot because we have become a lot more sick — more in need of help. Over the last 50 years, obesity has greatly increased. Diabetes has greatly increased. Depression has greatly increased. Depression, including subclinical depression, is now common and has so many bad effects or correlates — less activity, less socializing, less sunlight, poor sleep, less compliance with everything — that its impact on health must be great.

Abstracts from The New Yorker

The New Yorker now has online abstracts, just like scientific journals. From the abstract of an article by Patricia Marx:

The writer spies from her living-room window a multitude of colorful puffy parkas from Pucci (24 East 64th Street). The writer then calls Dr. Andrej Romanovsky to ask how the body detects cold. New York is the city of coats. Real coats, not car coats, for in this town, we walk. . . . Still worried about the coming cold? There is always one thing left to do: Miami (U.S. Airways; flights as low as $59 one-way).

Surely this is better than the article itself. Just as brandy is better than the wine it is distilled from.

How to Answer Your Critics

From Vanity Fair:

As for the thousand or so members of the online “Rachael Ray Sucks Community”—a pack who delight in obnoxious nicknames (Retchel, Raytard), mock her smile, hate her vocabulary (”yum-o” especially), criticize her over-reliance on canned chicken stock, and think she dresses like Greg on The Brady Bunch . . . Ray answers such critics by agreeing with them. “Most of what they say is absolutely true. I don’t know how to bake. I didn’t make my own pierogis in episode whatever. You can’t be all things to all people.”

Not bad.

Joyce Hatto and Ranjit Chandra: Separated at Birth?

In the current New Yorker, Mark Singer, one of my favorite writers, describes the “incredible career” of the late Joyce Hatto, a British pianist. According to her husband, she had a stillborn twin brother. Could that brother have in fact lived, and become Ranjit Chandra, a Canadian immunologist?

Consider the similarities:

1. Accolades. Toward the end of her life, Hatto released dozens of recordings that elicited great praise. “One of the greatest pianists I have ever heard,” said one critic. Chandra was awarded the Order of Canada, the country’s highest honor.

2. Man of mystery. Hatto recorded several concertos with Rene Kohler and the National Philharmonic-Symphony Orchestra but “there was no mention of him or the orchestra in any reference book,” according to Singer. Saul Sternberg and I could not locate Amrit L. Jain, author of a study with the same results as one of Chandra’s studies. Nor could we locate his institution (”Medical Clinic and Nursing Home”).

3. One strange fact after another. Many of Hatto’s performances were identical or almost identical to performances by others. As Saul Sternberg, Ken Carpenter, and I examined Chandra’s papers, we discovered many unlikely or impossible details. Our letters to editors about this are here and here.

More
about Chandra, who has sued the CBC (Canadian Broadcasting Corporation) over its documentary about him. Part 1 of that documentary, for which Chris O’Neill-Yates won a journalism award.

How Could We Be This Wrong about Medicine?

Robin Hanson’s excellent essay in Cato Unbound is a proposal to cut medical spending in half. The evidence suggests that this would do little harm and it would help us focus on more helpful activities. I like the way this article summarizes the RAND experiment, searches for the right metaphor, and answers objections.

One question Robin answers is “How could we be this wrong about medicine?” My answer is different than Robin’s. I point to the way many scholarly and scientific disciplines start off useful and become useless. In the case of medicine, the lack of benefit is easier to measure. Try measuring the value of a class in 18th Century English Literature.

Loneliness and National Security

This story — about an NSA employee named Gene Carson — by Igor Vamos is so strange and affecting I would have thought it made up (like Truman Capote’s snakes story) except that almost every detail rings true.

I remember when you used to tell me that fruit from the supermarket is tasteless. I agree with you. If small markets work, why do we need the super markets? I miss you.

This is one of Carson’s diary entries. “You” is Imogene Campbell, whom Carson wiretapped daily but never met.

Given how little I can learn about Gene Carson and Imogene Campbell via Google, maybe it is fiction. If so, Igor Vamos is a genius.

Addendum: I guess it’s fiction.