More Natto, Please


Natto. This is on the list because, for one, it’s one of the few foods I’ve eaten that I truly don’t like. But mainly, it’s here because we’ve really messed up the way we eat soy. Natto is fermented soybeans and very popular in Japan, which is where I had it. It’s becoming more popular here and this is most likely due to its health benefits. Nearly all the soy options we’re offered in the U.S. are non-fermented. The list of health benefits of fermented soy is a mile long. It’s associated with reducing the risk of cancer, minimizing the likelihood of blood clotting, aiding digestion, increasing blood circulation, an improved immune system, improving bone density, lessening the likelihood of heart attacks, more vibrant skin, and reducing the chance of balding. And it also has strong antibiotic properties, among other things. So you might want to ditch the soy crisps, soy ice cream, and your iced soy mochas and add some natto to your diet.

From 10 Foods You Should Eat. It’s a very reasonable list.

Diet and Acne

Two years ago I guest-blogged at the Freakonomics blog about diet and acne. I wrote that the claim of dermatologists that there is no link between diet and acne was absurd, not only because I had seen for myself such a link but also because it was an impossibly broad generalization.

In an article in the Boston Globe, Cynthia Graber, a science journalist, describes quite a bit of evidence that yes, diet affects acne. The research on which the no-link claim was based tested only two foods (chocolate and sugar)! From which committees of dermatologists generalized to all foods.

SO WHY HAVE DOCTORS been taught for so long that there’s no link? The anti-diet hypothesis . . . arose solely from two studies from the late 1960s and early 1970s. . . . One compares real chocolate bars with fake ones and was conducted at the University of Pennsylvania School of Medicine with funding from the Chocolate Manufacturers Association. . . . The other study examines sugar in the diet of a small group.

It’s like that scene in the Wizard of Oz where the Great Oz is revealed to be an ordinary man behind a curtain. All those knowledgeable-sounding claims by dermatologists, based on nothing more than this.

Conventional research on the subject is difficult, both because of funding problems — drug companies won’t fund such research; and dairy farmers won’t fund experiments to find out if dairy causes acne — and because it’s clear that many different foods are involved. On the other hand, determining the effect of Food X or Y on your own acne is easy. I wonder why someone doesn’t build a website to gather information from such self-experiments. If I had superpowers, I would.

More about diet and acne.

My Omega-3 Talk at Psychonomics

At the November meeting of the Psychonomic Society, a group of experimental psychologists, I gave a 15-minute talk (PowerPoint) about my omega-3 research. (Anyone know how to add audio to a PowerPoint file?) Almost all the data in the talk I’ve posted here, but it had one not-blogged idea, which I summarize like this:

optimize brain –> optimize body

The intake level of a nutrient that optimizes brain function should be close to the level that optimizes the function of everything else. In particular, the omega-3 intake that makes the brain work best should be close to the level that makes the rest of the body work best. This is because the brain and the rest of the body are bathed in the same blood.

It is easy to see why this is so. I have many electrical appliances: clock, telephone, TV, microwave, refrigerator, laser printer. In spite of vastly different innards and functions, all of them run best when their electrical supply is very close to house current. The electric current that makes my laser printer work best is very close to the electric current that makes my refrigerator work best. Of course, this is by design. LIkewise, the different parts of our body, although doing vastly different things, have all been adjusted by evolution to work best with the nutritional equivalent of house current. Just as we might study laser printers to learn what current to use with our refrigerator, we can study the brain to learn what nutrients optimize immune function.

This is a new idea in nutrition (at least, new to me). It is supported by and explains some of the most interesting data I’ve posted. It explains why Tyler Cowen’s gums got so much better so quickly — because he was taking almost exactly the best amount of flaxseed oil for his gums. Tyler chose his intake of flaxseed oil based on my behavioral data, which suggested the best amount was between 2 and 3 tablespoons/day. The gums and the brain could hardly be more different, but the best level for the brain turned out to do a wonderful job of healing his gums. Same thing with Anonymous and sports injuries.

By the way, this shows the scientific value of blogging. My gums got better, too, but not as impressively as Tyler’s. I didn’t have a lot of injuries to heal. The big improvements noticed by Tyler and Anonymous were “accidents” (unintended consequences). Science thrives on accidents; blogging, it turns out, is a new way to generate them.

Dietary Paradoxes and a Highly Anticipated Talk

Here’s a nice post about dietary puzzles in which a group of people who should have a high or low rate of heart disease don’t. For example,

Spanish paradox. Those naughty Spaniards are eating more fat and less carbs and getting LESS heart disease, now there’s a surprise. Good thing their medical system is so marvelous.

Sri Lanka paradox. In Sri Lanka they eat <25% calories from fat and still get lots of heart disease. Tut tut.

I have blogged about the Israeli Paradox. These paradoxes go away, the author notes, “when you realize saturated fat is not the cause of heart disease.”

Elsewhere on his blog he discusses studies that found that eating less fruits and vegetables improved health. Thanks to Dave Lull.

Not unrelated to all this, Ken Carpenter, a co-author of mine and an excellent speaker, is giving a talk next week in the Nutrition Department at UC Berkeley titled “When Nutritionists Go Wrong”. It is on Wednesday, December 19, 2007, at 4:10 pm Room 114 Morgan Hall. Ken has written wonderful books and articles about the history of nutrition and I am eagerly awaiting this talk.

Gary Taubes’s Berkeley Talk

Gary Taubes spoke at Berkeley a few weeks ago; the title of his talk was “The Quality of Calories: What Makes Us Fat and Why No One Seems to Care” (webcast). Did you know that the last edition of Dr. Spock’s baby book advocated a vegan diet? One of many fascinating details. Also this:

There’s a group at the University of Cincinnati that did an Atkins vs. low-fat study and they found that the Atkins people lost twice as much weight and they liked the diet much better. I was interviewing the dietitian who did the study. She had agreed to talk to me but she was very hesitant — she didn’t offer up any information. Finally, at the end of the interview, the one thing she offered freely: I asked her who funded it and she said the American Heart Association.

I said, “Well, I have to give them credit for funding it.”

She said, “Don’t. They funded it because we proposed it as a study that would refute the benefit. And when we found that the Atkins diet really worked and worked better than the low-calorie diet, now we’re trying to get money to look further into it and they won’t give it to us.”

Thanks to Dave Lull.

The Decline of Fact Checking at The New Yorker

In the latest New Yorker, an article by Bill Buford begins:

Meat-eaters . . . have more recently had to accept that their diet is probably the source of much of the world’s . . . obesity.

Gary Taubes’ new book Good Calories, Bad Calories argues the opposite. Even if the fact checkers hadn’t read Taubes, surely they knew of the Atkins diet?

Addendum: Buford also blames heart disease on meat. In this talk Malcolm Kendrick notes an inverse correlation between saturated fat consumption and heart disease. Thanks to Dave Lull.

Brian Wansink to the USDA!

Brian Wansink, author of Mindless Eating and an innovative methodologist, has been appointed executive director of the U.S. Department of Agriculture’s Center for Nutrition Policy and Promotion for 14 months. A surprising and most encouraging choice. Brian’s research is amazingly free of dogma. He does what you should do, rather than what people tell you to do.

About cool data.

How Bad is Saturated Fat?

This Men’s Health article is a nice summing-up of the lack of evidence that saturated fat is bad.

In 2000, a respected international group of scientists called the Cochrane Collaboration conducted a “meta-analysis” of the scientific literature on cholesterol-lowering diets. After applying rigorous selection criteria (219 trials were excluded), the group examined 27 studies involving more than 18,000 participants. Although the authors concluded that cutting back on dietary fat may help reduce heart disease, their published data actually shows that diets low in saturated fats have no significant effect on mortality, or even on deaths due to heart attacks. “I was disappointed that we didn’t find something more definitive,” says Lee Hooper, Ph.D., who led the Cochrane review. If this exhaustive analysis didn’t provide evidence of the dangers of saturated fat, says Hooper, it was probably because the studies reviewed didn’t last long enough, or perhaps because the participants didn’t lower their saturated-fat intake enough. Of course, there is a third possibility, which Hooper doesn’t mention: The diet-heart hypothesis is incorrect.

Thanks to Dave Lull.

Women’s Health Initiative

Here’s a nice essay about the Women’s Health Initiative, a nine-year mega-million-dollar experiment to measure the effect of “healthy eating” especially a low-fat diet.

48,835 postmenopausal women . . . were randomly assigned . . . to either their regular unrestricted diet or to a “healthy” diet that was low-fat (20% fat) and high fiber, with at least 5 servings of fruits and vegetables, and 6 servings of grains a day. The “healthy” eaters endured an “intense behavioral modification program by specially trained and certified professionals” to keep them on their diets. While they backslide a little, they did surprisingly well in sticking to the diet — as good as dietary prescripts will ever get and money can buy — at a cost of $8,498 spent per person!

Oops, no effect. “The results of this huge study, despite the hundreds of millions of dollars of taxpayer money spent on it, were quietly buried.”

I conclude two things: 1. People in charge of spending vast sums on nutrition research don’t know very much about what constitutes a healthy diet. 2. The same people know very little about how to do experiments. The most basic lesson is to do the smallest experiment possible.

Sandy Szwarc, the author of this essay, concludes:

When we enjoy a variety of foods from all of the food groups — as most everyone naturally does when they’re not trying to control their eating — and trust our bodies, we’ll get the nutrients we need to prevent deficiencies. And that is the only thing that nutritional science can credibly support.

There is some truth to this, both (a) we instinctively eat to avoid certain deficiencies and (b) nutrition science has found conclusive evidence that we need certain chemicals. But she is quite wrong in the sense that most Americans appear to suffer from huge omega-3 deficiencies (my posts about this). Many of them, probably most of them “enjoy a variety of foods from all of the food groups.”

Thanks to Dave Lull.

Better Nutrition, Better Behavior

Here is an abstract of an enormously interesting and already famous 2002 study of the effect of better nutrition on the behavior of prison inmates. The supplements included omega-3 fats.

The study was very innovative and no doubt extremely difficult. About as far from studying lab rats or college students as you can get. Here are the key results:

Those who received the active capsules committed on average 11.8 infringements per 1000 person-days, a reduction of 26.3% (95% CI 8.3-44.3%) compared to those who received placebos. This difference between groups was statistically significant at P<0.03 (two-tailed).

In spite of a huge effect — huge at least in practical terms — the statistical significance was marginal. There isn’t anything wrong with that, it indicates that we need a way of studying these very important issues that isn’t incredibly hard. Of course the “easy” method will be “deficient” (according to overly critical critics) in a dozen ways; that’s the price you pay. The authors of this article don’t entirely understand this point. “Further investigations should include assessments of nutritional status from blood before and during supplementation,” they write. Uh, no, you don’t always follow a very difficult thing by trying to do an even more difficult thing.

Nothing is said about the difficulty of the study, which is extremely important, in this report. The difficulty of a scientific study is always important but almost always goes unmentioned in scientific articles. If you (the reader) have done similar studies you can guess okay but with an innovative study like this few readers could have any clear idea.

Thanks to Dev Rana.