Tracking How Well My Brain is Working

From my omega-3 results I got the idea that our brains may work better or worse without our noticing. I want to track how well my brain works not only to test the effects of different dietary fats (our brain is more than half fat) but also to allow the possibility of discovering new effects, both good and bad.

One test I am using is a typing test (early results here). Another is an arithmetic test. I got the idea of using arithmetic from Tim Lundeen. Like him, I found that the speed with which I could do simple arithmetic problems (8+0, 4*3) was sensitive to the amount of omega-3 in my diet.

The arithmetic test involves doing 100 problems separated into 5 blocks of 20 each. There is little time between each problem. I type the last digit in the answer; e.g., if I see 8*8 I type 4. The possible answers are 1, 2, 3, 4, 7, 8, 9, and 0 so that I don’t have to move my fingers off the keys. There is feedback after each block. I aim for 95% correct.

This is my second use of an arithmetic test. The advantages of this one compared to several other tasks I have tried are:

  • Portable. Only requires a laptop.
  • Well-learned. So I should plateau (reach a steady speed) sooner than with a task I learn from scratch. When my speed is steady it will be easier to compare different conditions — no need to correct for learning.
  • Uses eight fingers. Many tasks used by experimental psychologists have just two possible answers (yes/no). With eight possible answers there is less anticipation and less worry about repetitive strain injury.
  • No data entry. The task is written in R, the language I use to analyze the data.
  • Many measurements per minute. This allows me to correct for problem difficulty and get a standard error for each test session.

Here are early results.

In the test sessions after January 1, two sets of points are above the line — I was slower than expected, in other words. Both came from test sessions about an hour or so after I woke up. At the time of those sessions I felt fine — not tired, not groggy — and was a little surprised. This is a trivial example of what I am looking for: new environmental effects.

The bigger context of this research is that scientists know a lot about idea testing but almost nothing about idea generation — how to find new ideas worth testing. Maybe this research will teach me something about idea generation.

A talk by Tim Lundeen about related stuff.

Does Innovation Require Markets?

Andrew Gelman's table

Andrew Gelman writes:

The article [about economics professor David Galenson] then quotes art professor Michael Rushton as saying that in science or art, “innovation really requires a market.” Huh? Wha?? Tell that to my friend Seth, who spent 10 years self-experimentation. Heck, tell that to the cave painters. Or check out the American Visionary Art Museum.

I agree. I was able to do self-experimentation for 10 years because I didn’t have to sell, i.e., publish it. Not having to sell — I mean publish — it gave me the freedom to do and think whatever I wanted for as long as I wanted.

Innovation benefits not from markets but from subsidies, which provide time to experiment. In my case, I was a professor at Berkeley — subsidized by the State of California. I had tenure and free time. Sometimes the subsidies aren’t obvious. Part of my theory of human evolution is that gifts, ceremonies, holidays, fashion, and connoisseurs, not to mention love of art, subsidized artists and artisans by providing a desire for work that — in the absence of gifts, etc. — would be much harder to make a living from. Helping artists and artisans make a living helped them advance their technology. Cave paintings may have been part of a holiday observance — the artists took time off from hunting. Before trade, Thorstein Veblen’s Instinct of Workmanship motivated innovation. Andrew himself built the table in the above photo for reasons that had nothing to do with markets.

But at least an economics professor is studying innovation. A few years ago in the Berkeley Public Library I picked up an introductory economics textbook. Six or seven hundred pages. Half a page on innovation!

Assorted Links

  1. Self-experiment on short-term memory announcement
  2. Why the Chinese government censors the Internet. James Fallows was able to figure out why they blocked the NY Times website for a few days (an article about suppression of rebellion).
  3. Nassim Taleb on iatrogenesis. “They never consider that “nothing” may be better than the best model.”
  4. The Lost Art of Walking by Geoff Nicholson.
  5. Best journalism of the year. More lists like this! One reason Spy was so good, I think, was that they covered stuff, especially New York publishing, that they knew about from personal experience. Like scientists writing about science.
  6. Six ballsiest scientific frauds.

Thanks to Dave Lull and Tyler Cowen.

A Self-Experimental Near-Miss

I am developing tests to measure how well my brain is working. Brief tests I can use daily. My experiences with flaxseed oil make me suspect that sometimes our brains work better and/or worse than usual for many hours or days at a time and this goes unnoticed. If these instances of better or worse function could be detected, maybe we could figure out their causes — and thereby improve how well our brains work by getting less bad stuff and more good stuff. In the case of flaxseed oil, I noticed that one morning my balance was much better than usual. I noticed this only because I was doing something unusual: putting on my shoes standing on one foot. I verified that observation with a better test of balance and later found that flaxseed oil improved my performance on several mental tests, such as speeded arithmetic.

One test I am using is a typing test: On each trial I type a random sequence of six letters four times. For example, if the sequence is “rksocn” I would type rksocnrksocnrksocnrksocn”. At the moment the measure of performance is how fast I type the 24-letter sequence. Each session consists of ten trials.

Here are the results so far:

old analysis

Each point is a mean over the ten trials; the error bars show standard errors. I was glad to see there was little sign of learning after the first few sessions. Having to correct for learning would make comparison of different days more difficult.

Because I am collecting a lot of data, I could look at these data more carefully. It took me a little while to do an analysis where I corrected for the difficulty of each string: Some will be easier to type than others. My first attempt at correction involved adding a factor for each letter: does the string contain an “a” (factor 1)? Does the string contain a “b” (factor 2)? And so on. This correction made a big difference: The residual mean square was almost cut in half (= sensitivity was doubled). After correcting for this, I got new estimates and standard errors for each test session:

new analysis

Uh-oh! The new analysis revealed there had been something unusual about the second-to-last test session — my typing had been distinctly slower than usual. Something I ate? Unfortunately, by the time I did this analysis I could no longer remember what might have been different.

The Benefits of Standing: The Clear Vial on the Right

This article says that a fat-digesting enzyme called lipase becomes inactive while sitting. The evidence, seen in the accompanying video, is extraordinary: a cloudy vial of blood (taken after a sitting meal) versus a much clearer vial of blood (taken from the same person after a standing meal.)

I found that a great increase in standing, lasting years, had no effect on my weight but I slept much better. I ate standing up much more often.

Another Link Between Better Sleep and Better Health

Much of my self-experimentation has been about improving my sleep — in particular, not waking up too early. I found that avoiding breakfast and standing a lot made a big difference. Currently I am studying the effect of stressing the leg muscles in other ways and will soon have more to say about this.

Now comes more evidence this matters: People who slept too little had a higher risk of coronary artery calcification.

JAMA abstract.

A Second Opinion: You’ve Been Poisoned by Your Doctor

In a wonderful profile of master diagnostician Dr. Thomas Bolte, this especially pleased me:

Many of the patients Bolte sees are victims of iatrogenic, or doctor-caused, illness. Simply put, they have been misdiagnosed, overmedicated to the point of sickness, or given treatment inappropriate to their conditions. On occasion, this has led to shouting matches with more conventional docs, like the dermatologist colleague who burst into Bolte’s office one day and harangued him—in front of another patient—for telling the mom of an acne-ridden teen to stop feeding her child so much junk food. There’s no evidence that diet has anything to do with acne, the dermatologist shouted. Bolte begged to differ and cited the literature. “The pharmaceutical industry has trained even doctors to believe that there’s a pharmaceutical answer to everything,” he says, shrugging.

A large fraction of Bolte’s patients have been poisoned. They get better when the poison is stopped. The mother of a friend of mine was near death — so near that her children decided to put her in a hospice. By mistake her six or seven medicines were stopped. And she recovered! Her medicines were what had been killing her.

The technical term for such horrors is drug interaction.

Thanks to Dave Lull.

100 Paper NY Times = 1 Heavy Textbook

Alana Taylor, a journalism student at NYU, blogged about one of her classes:

Quigley [the teacher] tells us we have to remember to bring in the hard copy of the New York Times every week. I take a deep sigh. Every single journalism class at NYU has required me to bring the bulky newspaper. I don’t understand why they don’t let us access the online version, get our current events news from other outlets, or even use our NYT imes app on the iPhone. Bringing the New York Times pains me because I refuse to believe that it’s the only source for credible news or Pulitzer Prize-winning journalism and it’s a big waste of trees. . . I am taking the only old-but-new-but-still-old media class in the country.

Yeah. The same thing goes on all over campus where students are required to buy a heavy glossy textbook that costs about a semester of paper New York Times. As if the same info wasn’t free on the Web.

Long ago, textbooks were a fantastic bargain because they cost so much less than private tutors. And private tutors disappeared.

After Taylor’s unflattering piece, her thin-skinned professor, who had said “it’s essential for journalists to blog”, banned blogging about the class.

Careful with the Sushi

I once lost about 12 pounds by eating lots of sushi. I didn’t think was a good long-term idea, however, because sushi was expensive and might have too much mercury. Now Jeremy Piven, best known as Ari in Entourage, has found that eating lots of sushi can indeed raise your mercury levels a significant amount. According to New York,

Dr. Carlon Coker went on record with Entertainment Tonight to confirm that Piven has six times the amount of mercury in his system that a healthy person should have, apparently a result of Piven’s insatiable appetite for sushi.

As a result he quit his role in David Mamet’s Speed the Plow. Mamet’s response:

I talked to Jeremy on the phone, and he told me that he discovered that he had a very high level of mercury. So my understanding is that he is leaving show business to pursue a career as a thermometer.

What a jerk.

The Twilight of Expertise (part 16: opticians)

These glasses can help everyone, not just the poor:

The wearer adjusts a dial on the syringe to add or reduce amount of fluid in the membrane, thus changing the power of the lens. When the wearer is happy with the strength of each lens the membrane is sealed by twisting a small screw, and the syringes removed. The principle is so simple, the team has discovered, that with very little guidance people are perfectly capable of creating glasses to their own prescription.

[Josh] Silver [a retired professor of physics] calls his flash of insight a “tremendous glimpse of the obvious” – namely that opticians weren’t necessary to provide glasses

Speaking of not needing opticians and making glasses more affordable, a year ago I discovered by accident something extremely useful: Wearing one contact lens is better than wearing two.

Wearing just one contact lens, I get good distance vision from the lensed eye and and good close-up vision from the unlensed eye. Wearing two contact lenses, I have poor close-up vision. Another benefit of one rather than two contact lenses is that one eye is contact-lens-free for a long time. And I go through contact lenses half as fast. I wear lenses that last one month so I switch monthly which eye has the lens.

No optician told me this. No optician has even figured this out, as far as I know.